RESPONSE: Re: Insulin Resistance and Prostate Cancer Risk

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Re: Insulin resistance and prostate cancer risk.

In three papers from the same case– control series recruited from Shanghai, China, Hsing et al. (1–3) have reported statistically significant associations between prostate cancer risk and aspects of insulin resistance syndrome. First, they observed an increase in prostate cancer risk associated with abdominal obesity, measured by waist-to-hip ratio (odds ratio [OR] ‫ס‬ 2.71 for highest versus l...

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Insulin resistance and prostate cancer risk.

Because high waist-to-hip ratio (WHR) and high serum insulin levels have been reported to be associated with an increased risk of prostate cancer, we assessed the relationship between insulin resistance and prostate cancer risk in Chinese men. We measured fasting serum glucose and insulin levels in 128 case and 306 control subjects and used the homeostasis model assessment to derive indices of ...

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Insulin resistance-related gene polymorphisms and risk of prostate cancer.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland; Information Management Services, Inc., Silver Spring, Maryland; Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut; Department of Health Promotion and Chronic Disease Prevention, National Public Health In...

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Serum insulin, glucose, indices of insulin resistance, and risk of prostate cancer.

BACKGROUND The mitogenic and growth-stimulatory effects of insulin-like growth factors appear to play a role in prostate carcinogenesis, yet any direct association of circulating insulin levels and risk of prostate cancer remains unclear. METHODS We investigated the relationship of the level of serum insulin, glucose, and surrogate indices of insulin resistance (ie, the molar ratio of insulin...

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Insulin resistance, obesity and breast cancer risk.

Breast cancer (BC) is one of the most important problems of public health. Among the avoidable risk factors during a woman's life, overweight and obesity are very important ones. Furthermore they are increasing worldwide. The risk of breast cancer is traditionally linked to obesity in postmenopausal women; conversely, it is neutral or even protective in premenopausal women. Since the initiator ...

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ژورنال

عنوان ژورنال: JNCI Journal of the National Cancer Institute

سال: 2003

ISSN: 0027-8874,1460-2105

DOI: 10.1093/jnci/95.14.1087